Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to late endosome transport; endosome to lysosome transport; and protein targeting to lysosome. Located in early endosome; endosome membrane; and late endosome.
RGD Description
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]