Species

Homo sapiens

Symbol

CSNK2B

Name

casein kinase 2 beta

Synonyms

alternative name: G5a, phosvitin
casein kinase 2, beta polypeptide

Biotype

protein coding gene

Automated Description

Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and identical protein binding activity. Involved in several processes, including adiponectin-activated signaling pathway; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and symbiont-mediated disruption of host cell PML body. Located in PcG protein complex; cytoplasm; and plasma membrane. Part of protein kinase CK2 complex. Is active in PML body and chromatin. Biomarker of leiomyoma.

RGD Description

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR11740

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

None

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

No data available

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr6:31665227...31670343 + (5.12 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

CSNK2B molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

CSNK2B role	CSNK2B genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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