Version: 8.0.0Date: Tue Jan 28 2025
Gene
KCNE2
- Species
- Homo sapiens
- Symbol
- KCNE2
- Name
- potassium voltage-gated channel subfamily E regulatory subunit 2
- Synonyms
- ATFB4
- cardiac voltage-gated potassium channel accessory subunit 2
- Biotype
- protein coding gene
- Automated Description
- Enables potassium channel regulator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Contributes to delayed rectifier potassium channel activity and inward rectifier potassium channel activity. Involved in several processes, including membrane repolarization during ventricular cardiac muscle cell action potential; negative regulation of delayed rectifier potassium channel activity; and potassium ion transmembrane transport. Located in cell surface and voltage-gated potassium channel complex. Implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6.
- RGD Description
- Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR15282
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr21:34180729...34371381 + (190.65 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.