Version: 8.0.0Date: Tue Jan 28 2025
Gene
ATF4
- Species
- Homo sapiens
- Symbol
- ATF4
- Name
- activating transcription factor 4
- Synonyms
- activating transcription factor atf-4
- cAMP response element-binding protein 2
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including identical protein binding activity; leucine zipper domain binding activity; and promoter-specific chromatin binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to leucine starvation; integrated stress response signaling; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including Lewy body core; centrosome; and nuclear lumen. Part of ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; and CHOP-ATF4 complex. Implicated in prostate carcinoma.
- RGD Description
- This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13044
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr22:39519695...39522686 + (2.99 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.