Gene

PAK2

Species
Homo sapiens
Symbol
PAK2
Name
p21 (RAC1) activated kinase 2
Synonyms
  • gamma-PAK
  • KNO2
Biotype
protein coding gene
Automated Description
Enables several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including cell-cell junction assembly; regulation of apoptotic process; and regulation of protein metabolic process. Acts upstream of or within protein autophosphorylation. Located in cell-cell junction and cytosol. Is active in cytoplasm and nucleus. Implicated in ductal carcinoma in situ.
RGD Description
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

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      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PAK2 molecule type
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            Genetic Interactions

            PAK2 role
            PAK2 genetic perturbation
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