Version: 8.0.0
Date: Tue Jan 28 2025
PIK3C2G
Homo sapiensHGNC:8973
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

PIK3C2G

Species
Homo sapiens
Symbol
PIK3C2G
Name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Synonyms
  • MGC163149
  • phosphatidylinositol 3-kinase C2 domain-containing gamma
Biotype
protein coding gene
Automated Description
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; phosphatidylinositol-3-phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Implicated in type 2 diabetes mellitus.
RGD Description
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusPik3c2g10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusPik3c2g10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Danio reriopik3c2g7 of 10YesYes☑ ☑☐☐☑☐☑☑☑ ☑
Drosophila melanogasterPi3K68D4 of 9YesNo☑ ☐☐☐☑☐☑☑☐  
Caenorhabditis eleganspiki-17 of 9YesNo☑ ☐☑☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            PIK3C2G molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              PIK3C2G role
              PIK3C2G genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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