Version: 8.0.0
Date: Tue Jan 28 2025
Ctnnbip1
Mus musculusMGI:1915756
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ctnnbip1

Species
Mus musculus
Symbol
Ctnnbip1
Name
catenin beta interacting protein 1
Synonyms
  • 1110008O09Rik
  • 2310001I19Rik
Biotype
protein coding gene
Automated Description
Enables beta-catenin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of smooth muscle cell proliferation; and regulation of DNA-templated transcription. Acts upstream of or within anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; and negative regulation of Wnt signaling pathway. Part of beta-catenin-ICAT complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1).
MGI Description
PHENOTYPE: Homozygous null mice display neonatal lethality associated with rupture of the gut, posteriorized neural cell fate within the neural plate, abnormal craniofacial morphology, and renal agenesis due to arrest of ureteric bud branching. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47142
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ctnnbip1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            Ctnnbip1 role
            Ctnnbip1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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