Gene

Prdm13

Species
Mus musculus
Symbol
Prdm13
Name
PR domain containing 13
Synonyms
None
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and histone methyltransferase activity. Involved in GABAergic neuron differentiation and hypothalamus cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II and neurogenesis. Located in nucleus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PRDM13 (PR/SET domain 13).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele show a specific reduction in the number of GABAergic and glycinergic amacrine cells, a thin retinal inner nuclear layer, altered retinal inner plexiform layer morphology, and abnormally increased spatial, temporal, and contrast sensitivities in optokinetic reponses. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16515
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
21.678M21.679M21.680M21.681M21.682M21.683M21.684M21.685M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions