Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and histone methyltransferase activity. Involved in GABAergic neuron differentiation and hypothalamus cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II and neurogenesis. Located in nucleus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PRDM13 (PR/SET domain 13).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele show a specific reduction in the number of GABAergic and
glycinergic amacrine cells, a thin retinal inner nuclear layer, altered retinal inner plexiform layer morphology, and abnormally increased spatial, temporal, and contrast sensitivities in optokinetic reponses. [provided by MGI curators]