Gene

Ikbke

Species
Rattus norvegicus
Symbol
Ikbke
Name
inhibitor of nuclear factor kappa B kinase subunit epsilon
Synonyms
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • inhibitor of kappaB kinase epsilon
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of gene expression; and positive regulation of innate immune response. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon).
RGD Description
Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of innate immune response; and regulation of gene expression. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22969
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
42.715M42.720M42.725M42.730M42.735M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions