Version: 8.0.0
Date: Tue Jan 28 2025
Fkbp6
Rattus norvegicusRGD:1308926
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fkbp6

Species
Rattus norvegicus
Symbol
Fkbp6
Name
FKBP prolyl isomerase family member 6
Synonyms
  • 36 kDa FK506 binding protein
  • FK506 binding protein 6
Biotype
protein coding gene
Automated Description
Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)).
RGD Description
Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)); INTERACTS WITH bisphenol A; 17alpha-ethynylestradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46674
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFKBP610 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusFkbp69 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisfkbp65 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriofkbp69 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogastershu9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Fkbp5140440242 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp4239738252 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp8332440262 of 9☑☐☐☐☐☐☐☑☐ 
Fkbpl428136242 of 9☑☐☐☐☐☐☐☑☐ 
Ttc9c517349282 of 9☑☐☐☐☐☐☐☑☐ 
Ttc9621437222 of 9☑☐☐☐☐☐☐☑☐ 
Ttc9b719039242 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp2811948342 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp1a910554372 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp101010950332 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp9119847332 of 9☑☐☐☐☐☐☐☑☐ 
Fkbp1b121456562 of 9☑☐☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051347.1:g.21320050A>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.21346745G>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.21378073G>Tvariant
    SNP
    • intron variant
    NC_051347.1:g.21378714G>Avariant
    SNP
    • intron variant
    NC_051347.1:g.21319089G>Avariant
    SNP
    • intron variant
    NC_051347.1:g.21320897T>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.21323854T>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.21324462G>Avariant
    SNP
    • intron variant
    NC_051347.1:g.21325289G>Avariant
    SNP
    • intron variant
    NC_051347.1:g.21328031C>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 148 rows
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available