Gene

Dmpk

Species
Rattus norvegicus
Symbol
Dmpk
Name
DM1 protein kinase
Synonyms
  • Dm15
  • dystrophia myotonica kinase, B15
Biotype
protein coding gene
Automated Description
Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase).
RGD Description
Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22988
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
78.731M78.732M78.733M78.734M78.735M78.736M78.737M78.738M78.739M78.740M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions