Gene

Tnnc1

Species
Rattus norvegicus
Symbol
Tnnc1
Name
troponin C1, slow skeletal and cardiac type
Synonyms
  • LOC290561
  • Tncc
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity. Involved in cardiac muscle contraction; diaphragm contraction; and response to metal ion. Located in contractile muscle fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).
RGD Description
Enables calcium ion binding activity. Involved in cardiac muscle contraction; diaphragm contraction; and response to metal ion. Located in contractile muscle fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23048
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTNNC110 of 10YesYes  
Mus musculusTnnc19 of 9YesYes   
Xenopus tropicalistnnc19 of 9YesYes   
Danio reriotnnc1a9 of 9YesYes   
Danio reriotnnc1b3 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Tnnc2116180653 of 9 
Pdcd6212346252 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
6.4010M6.4015M6.4020M6.4025M6.4030M6.4035M6.4040M6.4045M6.4050M6.4055M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051351.1:g.6404322C>Tvariant
SNP
  • intron variant
NC_051351.1:g.6404919C>Tvariant
SNP
  • intron variant
NC_051351.1:g.6403059G>Avariant
SNP
  • intron variant
NC_051351.1:g.6403072G>Avariant
SNP
  • intron variant
NC_051351.1:g.6404844C>Tvariant
SNP
  • intron variant
NC_051351.1:g.6405230G>Avariant
SNP
  • missense variant
NC_051351.1:g.6403057T>Avariant
SNP
  • intron variant
NC_051351.1:g.6403519C>Tvariant
SNP
  • intron variant
NC_051351.1:g.6405275C>Tvariant
SNP
  • 3 prime UTR variant
NC_051351.1:g.6402398G>Avariant
SNP
  • intron variant
Showing 1 - 10 of 28 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(Myh6/tetO-Tnnc1*I61Q)1Jmol
Yes
Mus musculusTg(Myh6/tetO-Tnnc1*L48Q)2Jmol
Yes
Showing 1 - 2 of 2 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
6.4010M6.4015M6.4020M6.4025M6.4030M6.4035M6.4040M6.4045M6.4050M6.4055MENSRNOT00000025606.7 (Tnnc1)ENSRNOT00000094646.1 (Tnnc1)NM_001034105.2 (Tnnc1)XM_039094265.2 (Tnnc1)ENSRNOT00000110415.1 (ENSRNOG00000069702)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Tnnc1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
RNF207Homo sapiens
protein
  • affinity chromatography technology
PMID:35352799
protein
Tnnc1Rattus norvegicus
protein
  • x-ray crystallography
PMID:12501194
protein
Tnni3Mus musculus
protein
  • x-ray crystallography
PMID:12501194
Showing 1 - 3 of 3 rows
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Genetic Interactions

No data available