Gene

Eps8

Species
Rattus norvegicus
Symbol
Eps8
Name
EGFR pathway substrate 8, signaling adaptor
Synonyms
  • epidermal growth factor receptor kinase substrate 8
  • epidermal growth factor receptor pathway substrate 8
Biotype
protein coding gene
Automated Description
Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in several processes, including actin filament organization; barbed-end actin filament capping; and small GTPase-mediated signal transduction. Predicted to act upstream of or within several processes, including adult locomotory behavior; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor).
RGD Description
Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in several processes, including actin filament organization; barbed-end actin filament capping; and small GTPase-mediated signal transduction. Predicted to act upstream of or within several processes, including adult locomotory behavior; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12287
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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170.39M170.40M170.41M170.42M170.43M170.44M170.45M170.46M170.47M170.48M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions