Gene

Mc1r

Species
Rattus norvegicus
Symbol
Mc1r
Name
melanocortin 1 receptor
Synonyms
  • AC132057.1
  • alpha melanocyte stimulating hormone receptor
Biotype
protein coding gene
Automated Description
Enables hormone binding activity and melanocortin receptor activity. Involved in positive regulation of feeding behavior. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor).
RGD Description
Enables hormone binding activity and melanocortin receptor activity. Involved in positive regulation of feeding behavior. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH acrolein; thioacetamide; (-)-epigallocatechin 3-gallate (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22750
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
51.4525M51.4530M51.4535M51.4540M51.4545M51.4550M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions