Version: 8.0.0Date: Tue Jan 28 2025
Gene
Noto
- Species
- Rattus norvegicus
- Symbol
- Noto
- Name
- notochord homeobox
- Synonyms
- homeobox protein notochord
- LOC502857
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; motile cilium assembly; and regulation of cilium assembly. Predicted to be active in nucleus. Orthologous to human NOTO (notochord homeobox).
- RGD Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; motile cilium assembly; and regulation of cilium assembly. Predicted to be active in nucleus. Orthologous to human NOTO (notochord homeobox); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24339
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | NOTO | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Mus musculus | Noto | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | not | 2 of 9 | Yes | Yes | ☑ ☐☐☐☑☐☐☐☐ |
| Danio rerio | noto | 2 of 9 | Yes | Yes | ☑ ☐☐☐☑☐☐☐☐ |
| Drosophila melanogaster | CG18599 | 2 of 9 | Yes | Yes | ☑ ☐☐☐☑☐☐☐☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| Emx1 | 1 | 297 | 35 | 28 | 2 of 9 | ☐☐☐☐☐☐☑☑☐ |
| Emx2 | 2 | 234 | 38 | 28 | 2 of 9 | ☐☐☐☐☐☐☑☑☐ |
| Obox2l1 | 3 | 170 | 43 | 24 | 2 of 9 | ☐☐☐☐☐☐☑☑☐ |
| Gsx1 | 4 | 91 | 52 | 40 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
| Vax2 | 5 | 76 | 64 | 43 | 2 of 9 | ☐☐☐☐☐☐☑☑☐ |
| Vax1 | 6 | 59 | 71 | 51 | 2 of 9 | ☐☐☐☐☐☐☑☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
Showing 0 - 0 of 0 rows
per page
Alleles and Variants
- Genome location
- Chr4:117961163...117965402 + (4.24 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_051339.1:g.117962083T>A | variant | SNP
| |||||
| NC_051339.1:g.117961851G>A | variant | SNP
| |||||
| NC_051339.1:g.117962095A>T | variant | SNP
| |||||
| NC_051339.1:g.117963975C>T | variant | SNP
| |||||
| NC_051339.1:g.117962087T>A | variant | SNP
| |||||
| NC_051339.1:g.117962099T>A | variant | SNP
| |||||
Showing 1 - 6 of 6 rows
per page
Sequence Feature Viewer
- Genome location
- Chr4:117961163...117965402 + (4.24 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction