Gene

Nkx3-2

Species
Rattus norvegicus
Symbol
Nkx3-2
Name
NK3 homeobox 2
Synonyms
  • homeobox protein Nkx-3.2
  • LOC682329
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of chondrocyte differentiation; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including intestinal epithelial cell development; middle ear morphogenesis; and skeletal system development. Predicted to be active in nucleus. Orthologous to human NKX3-2 (NK3 homeobox 2).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of chondrocyte differentiation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including intestinal epithelial cell development; middle ear morphogenesis; and skeletal system development. Orthologous to human NKX3-2 (NK3 homeobox 2); INTERACTS WITH bisphenol A; 17beta-estradiol (ortholog); 17beta-hydroxy-5alpha-androstan-3-one (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
69.1838M69.1840M69.1842M69.1844M69.1846M69.1848M69.1850M69.1852M69.1854M69.1856M69.1858M69.1860M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions