Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1).
RGD Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH bisphenol A; methimazole; paracetamol.