Gene

Mnx1

Species
Rattus norvegicus
Symbol
Mnx1
Name
motor neuron and pancreas homeobox 1
Synonyms
  • Hlxb9
  • homeobox gene HB9
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1).
RGD Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH bisphenol A; methimazole; paracetamol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24335
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
5.8670M5.8675M5.8680M5.8685M5.8690M5.8695M5.8700M5.8705M5.8710M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions