Version: 8.0.0
Date: Tue Jan 28 2025
Macrod2
Rattus norvegicusRGD:1591318
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Macrod2

Species
Rattus norvegicus
Symbol
Macrod2
Name
mono-ADP ribosylhydrolase 2
Synonyms
  • AABR07054000.1
  • ADP-ribose glycohydrolase MACROD2
Biotype
protein coding gene
Automated Description
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in several processes, including DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2).
RGD Description
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in several processes, including DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; atrazine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11106
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Macrod2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Macrod2 role
            Macrod2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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