Version: 8.0.0
Date: Tue Jan 28 2025
Nqo1
Rattus norvegicusRGD:2503
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nqo1

Species
Rattus norvegicus
Symbol
Nqo1
Name
NAD(P)H quinone dehydrogenase 1
Synonyms
  • azoreductase
  • Dia4
Biotype
protein coding gene
Automated Description
Enables NAD(P)H dehydrogenase (quinone) activity; NADH:ubiquinone reductase (non-electrogenic) activity; and superoxide dismutase activity. Involved in several processes, including nicotinamide nucleotide metabolic process; regulation of apoptotic process; and response to ischemia. Located in dendrite and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including brain disease (multiple); liver disease (multiple); overactive bladder syndrome; prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1).
RGD Description
Enables NAD(P)H dehydrogenase (quinone) activity; NADH:ubiquinone reductase (non-electrogenic) activity; and superoxide dismutase activity. Involved in several processes, including nicotinamide nucleotide metabolic process; regulation of apoptotic process; and response to ischemia. Located in dendrite and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including brain disease (multiple); liver disease (multiple); overactive bladder syndrome; prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH (+)-catechin; (-)-selegiline; (3,4-dihydroxyphenyl)acetic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10204
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nqo1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Nqo1 role
            Nqo1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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