Version: 8.1.0
Date: Fri Apr 18 2025
Hbegf
Rattus norvegicusRGD:2526
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hbegf

Species
Rattus norvegicus
Symbol
Hbegf
Name
heparin-binding EGF-like growth factor
Synonyms
  • diphtheria toxin receptor
  • Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
Biotype
protein coding gene
Automated Description
Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space and plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor).
RGD Description
Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space and plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10740
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hbegf molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Hbegf role
            Hbegf genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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