Version: 8.0.0
Date: Tue Jan 28 2025
Kcnj3
Rattus norvegicusRGD:2958
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kcnj3

Species
Rattus norvegicus
Symbol
Kcnj3
Name
potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms
  • G protein-activated inward rectifier potassium channel 1
  • GIRK-1
Biotype
protein coding gene
Automated Description
Enables G-protein activated inward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Contributes to inward rectifier potassium channel activity. Involved in response to electrical stimulus. Located in T-tubule and external side of plasma membrane. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3).
RGD Description
Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in response to electrical stimulus. Located in T-tubule and external side of plasma membrane. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11767
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kcnj3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Kcnj3 role
            Kcnj3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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