Version: 8.1.0Date: Fri Apr 18 2025
Gene
Smad2
- Species
- Rattus norvegicus
- Symbol
- Smad2
- Name
- SMAD family member 2
- Synonyms
- MAD (mothers against decapentaplegic Drosophila) homolog 2
- MAD (mothers against decapentaplegic, Drosophila) homolog 2
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to glucose stimulus; and regulation of gene expression. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
- RGD Description
- Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to glucose stimulus; and regulation of gene expression. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13703
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr18:69849884...69918926 + (69.04 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.