Species

Rattus norvegicus

Symbol

Pklr

Name

pyruvate kinase L/R

Synonyms

L-PK
PK1

Biotype

protein coding gene

Automated Description

Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to insulin stimulus; and monocarboxylic acid metabolic process. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 2; malaria; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R).

RGD Description

Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to insulin stimulus; and pyruvate metabolic process. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 2; malaria; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; Fanconi syndrome pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR11817

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr2:174543008...174551870 + (8.86 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Pklr molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Pklr role	Pklr genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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