Gene

Tgfa

Species
Rattus norvegicus
Symbol
Tgfa
Name
transforming growth factor alpha
Synonyms
  • protransforming growth factor alpha
  • RATTGFAA
Biotype
protein coding gene
Automated Description
Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha).
RGD Description
Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 1,3-dinitrobenzene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10740
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
118.62M118.63M118.64M118.65M118.66M118.67M118.68M118.69M118.70M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions