Gene

Hhex

Species
Rattus norvegicus
Symbol
Hhex
Name
hematopoietically expressed homeobox
Synonyms
  • hematopoietically-expressed homeobox protein HHEX
  • Hex
Biotype
protein coding gene
Automated Description
Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-DNA complex. Orthologous to human HHEX (hematopoietically expressed homeobox).
RGD Description
Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-DNA complex. Orthologous to human HHEX (hematopoietically expressed homeobox); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24324
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
235.1905M235.1910M235.1915M235.1920M235.1925M235.1930M235.1935M235.1940M235.1945M235.1950M235.1955M235.1960M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions