Version: 8.0.0Date: Tue Jan 28 2025
Gene
Mapk8
- Species
- Rattus norvegicus
- Symbol
- Mapk8
- Name
- mitogen-activated protein kinase 8
- Synonyms
- c-Jun N-terminal kinase 1
- c-jun NH2-terminal kinase
- Biotype
- protein coding gene
- Automated Description
- Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
- RGD Description
- Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (R)-lipoic acid.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24055
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr16:8638897...8721981 - (83.08 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.