Species

Rattus norvegicus

Symbol

Disc1

Name

DISC1 scaffold protein

Synonyms

disrupted in schizophrenia 1
disrupted in schizophrenia 1 homolog

Biotype

protein coding gene

Automated Description

Enables kinesin binding activity. Involved in several processes, including positive regulation of cell projection organization; protein localization to centrosome; and pyramidal neuron migration to cerebral cortex. Acts upstream of or within regulation of glutamatergic synaptic transmission. Located in several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Part of dynein complex and kinesin complex. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein).

RGD Description

Enables kinesin binding activity. Involved in several processes, including positive regulation of cell projection organization; protein localization to centrosome; and pyramidal neuron migration to cerebral cortex. Acts upstream of or within regulation of glutamatergic synaptic transmission. Located in several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Part of dynein complex and kinesin complex. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR14332

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

Phenotype Term	Annotation details	References
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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr19:53014201...53223617 + (209.42 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Disc1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Disc1 role	Disc1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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