Version: 8.0.0Date: Tue Jan 28 2025
Gene
Ccl5
- Species
- Rattus norvegicus
- Symbol
- Ccl5
- Name
- C-C motif chemokine ligand 5
- Synonyms
- C-C motif chemokine 5
- chemokine (C-C motif) ligand 5
- Biotype
- protein coding gene
- Automated Description
- Enables chemokine activity and heparin binding activity. Involved in several processes, including lymphocyte migration; positive regulation of cell differentiation; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; metabolic dysfunction-associated steatotic liver disease; and orchitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; liver disease (multiple); lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).
- RGD Description
- Enables chemokine activity and heparin binding activity. Involved in several processes, including lymphocyte migration; positive regulation of cell differentiation; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; metabolic dysfunction-associated steatotic liver disease; and orchitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; liver disease (multiple); lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5); PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12015
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr10:68322826...68327380 - (4.55 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.