Version: 8.0.0Date: Tue Jan 28 2025
Gene
Cdkn1a
- Species
- Rattus norvegicus
- Symbol
- Cdkn1a
- Name
- cyclin-dependent kinase inhibitor 1A
- Synonyms
- Cip1
- cyclin-dependent kinase inhibitor 1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).
- RGD Description
- Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-dexrazoxane; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46778
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr20:7149177...7159727 + (10.55 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.