Species

Rattus norvegicus

Symbol

Eif2ak3

Name

eukaryotic translation initiation factor 2 alpha kinase 3

Synonyms

eukaryotic translation initiation factor 2-alpha kinase 3
pancreatic eIF2-alpha kinase

Biotype

protein coding gene

Automated Description

Enables Hsp90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).

RGD Description

Enables Hsp90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR11042

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

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Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr4:102805495...102866914 + (61.42 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Eif2ak3 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Eif2ak3 role	Eif2ak3 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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