Version: 8.0.0
Date: Tue Jan 28 2025
STE20
Saccharomyces cerevisiaeSGD:S000000999
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

STE20

Species
Saccharomyces cerevisiae
Symbol
STE20
Name
STErile
Synonyms
  • YHL007C
Biotype
protein coding gene
Automated Description
Enables MAP kinase kinase kinase kinase activity and histone H2BS14 kinase activity. Involved in several processes, including bipolar cellular bud site selection; intracellular signal transduction; and negative regulation of macromolecule biosynthetic process. Located in several cellular components, including incipient cellular bud site; mating projection tip; and nucleus. Human ortholog(s) of this gene implicated in breast cancer; ductal carcinoma in situ; non-syndromic X-linked intellectual disability 30; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PAK2 (p21 (RAC1) activated kinase 2); and PAK3 (p21 (RAC1) activated kinase 3).
SGD Description
Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015:SF35
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          STE20 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            STE20 role
            STE20 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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