Version: 8.0.0
Date: Tue Jan 28 2025
TPK3
Saccharomyces cerevisiaeSGD:S000001649
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

TPK3

Species
Saccharomyces cerevisiae
Symbol
TPK3
Name
Takashi's Protein Kinase
Synonyms
  • YKL166C
Biotype
protein coding gene
Automated Description
Enables cAMP-dependent protein kinase activity. Involved in several processes, including intracellular signal transduction; negative regulation of cytoplasmic mRNA processing body assembly; and negative regulation of cytoplasmic translation. Located in P-body; cytoplasmic stress granule; and nucleus. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha); PRKACB (protein kinase cAMP-activated catalytic subunit beta); and PRKACG (protein kinase cAMP-activated catalytic subunit gamma).
SGD Description
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24353:SF140
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          TPK3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            TPK3 role
            TPK3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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