Version: 8.0.0Date: Tue Jan 28 2025
Gene
PRP16
- Species
- Saccharomyces cerevisiae
- Symbol
- PRP16
- Name
- Pre-mRNA Processing
- Synonyms
- PRP23
- RNA16
- Biotype
- protein coding gene
- Automated Description
- Enables ATP-dependent activity, acting on RNA. Contributes to second spliceosomal transesterification activity. Involved in RNA exon ligation; generation of catalytic spliceosome for second transesterification step; and snRNA modification. Part of U2-type catalytic step 2 spliceosome. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38).
- SGD Description
- DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR18934:SF91
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXI:599857...603072 + (3.22 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.