Gene

VAS1

Species
Saccharomyces cerevisiae
Symbol
VAS1
Name
VAlyl-tRNA Synthetase
Synonyms
  • YGR094W
Biotype
protein coding gene
Automated Description
Enables sequence-specific mRNA binding activity and valine-tRNA ligase activity. Involved in valyl-tRNA aminoacylation. Located in mitochondrion. Used to study combined oxidative phosphorylation deficiency 20; mitochondrial encephalomyopathy; mitochondrial metabolism disease; and myoclonic-atonic epilepsy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to several human genes including VARS1 (valyl-tRNA synthetase 1).
SGD Description
Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11946:SF93
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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672.5k673.0k673.5k674.0k674.5k675.0k675.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions