Enables sequence-specific mRNA binding activity and valine-tRNA ligase activity. Involved in valyl-tRNA aminoacylation. Located in mitochondrion. Used to study combined oxidative phosphorylation deficiency 20; mitochondrial encephalomyopathy; mitochondrial metabolism disease; and myoclonic-atonic epilepsy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to several human genes including VARS1 (valyl-tRNA synthetase 1).
SGD Description
Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant