Version: 8.0.0
Date: Tue Jan 28 2025
SOD1
Saccharomyces cerevisiaeSGD:S000003865
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

SOD1

Species
Saccharomyces cerevisiae
Symbol
SOD1
Name
SuperOxide Dismutase
Synonyms
  • CRS4
  • YJR104C
Biotype
protein coding gene
Automated Description
Enables oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor and superoxide dismutase activity. Involved in several processes, including fungal-type cell wall organization; intracellular monoatomic cation homeostasis; and protein stabilization. Located in mitochondrial intermembrane space and nucleus. Is active in cytosol. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including SOD1 (superoxide dismutase 1).
SGD Description
Cytosolic copper-zinc superoxide dismutase; also sulfide oxidase; detoxifies superoxide and hydrogen sulfide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; abundance increases under DNA replication stress; localization to mitochondrial intermembrane space is modulated by MICOS complex; human ortholog SOD1 implicated in ALS complements a null allele
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10003:SF71
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          SOD1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            SOD1 role
            SOD1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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