Version: 8.0.0
Date: Tue Jan 28 2025
YPT6
Saccharomyces cerevisiaeSGD:S000004252
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

YPT6

Species
Saccharomyces cerevisiae
Symbol
YPT6
Name
Yeast Protein Two
Synonyms
  • YLR262C
Biotype
protein coding gene
Automated Description
Enables GTPase activity. Involved in several processes, including Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and protein localization to phagophore assembly site. Located in cis-Golgi network and cytosol. Is active in phagophore assembly site. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family); RAB6C (RAB6C, member RAS oncogene family); and RAB6D (RAB6D, member RAS oncogene family).
SGD Description
Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; GTP-bound Ypt6p temporarily localizes to the Golgi, and dissociates from the membrane into its GDP-bound cytosolic form after Gyp6p GAP is recruited by Ypt32p, a late Golgi GTPase; required for anterograde trafficking of Atg9p to the PAS during starvation-induced autophagy under heat stress, and for the CVT pathway; activated by the Ric1-Rgp1 GEF complex; homolog of mammalian Rab6
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24073:SF352
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          YPT6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            YPT6 role
            YPT6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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