Version: 8.0.0
Date: Tue Jan 28 2025
TSA1
Saccharomyces cerevisiaeSGD:S000004490
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

TSA1

Species
Saccharomyces cerevisiae
Symbol
TSA1
Name
Thiol-Specific Antioxidant
Synonyms
  • cTPxI
  • TPX1
Biotype
protein coding gene
Automated Description
Enables several functions, including ribosome binding activity; thioredoxin peroxidase activity; and unfolded protein binding activity. Involved in several processes, including DNA protection; cell redox homeostasis; and cellular response to dithiothreitol. Located in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32 and methylmalonic aciduria and homocystinuria type cblC. Orthologous to several human genes including PRDX1 (peroxiredoxin 1); PRDX2 (peroxiredoxin 2); and PRDX4 (peroxiredoxin 4).
SGD Description
Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form a HMW chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; hydrogen peroxide receptor and signal transducer in a light sensing pathway; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases and forms cytoplasmic foci during DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10681:SF128
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          TSA1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            TSA1 role
            TSA1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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