Gene

VPS20

Species
Saccharomyces cerevisiae
Symbol
VPS20
Name
Vacuolar Protein Sorting
Synonyms
  • CHM6
  • VPL10
Biotype
protein coding gene
Automated Description
Involved in ATP export; intralumenal vesicle formation; and late endosome to vacuole transport. Located in endoplasmic reticulum. Part of ESCRT III complex. Orthologous to human CHMP6 (charged multivesicular body protein 6).
SGD Description
Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22761:SF5
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCHMP67 of 9YesYes   
Mus musculusChmp67 of 9YesYes   
Rattus norvegicusChmp67 of 9YesYes   
Xenopus tropicalischmp67 of 9YesYes   
Danio reriochmp6a7 of 9YesYes   
Danio reriochmp6b7 of 9YesYes   
Drosophila melanogasterVps207 of 9YesYes   
Caenorhabditis elegansvps-207 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal chemical compound accumulation
abnormal colony appearance
abnormal protein/peptide distribution
abnormal replicative lifespan
abnormal subcellular morphology
abnormal vacuolar morphology
abnormal vacuolar transport
absent invasive growth
absent pseudohyphal growth
absent respiratory growth
Showing 1 - 10 of 48 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
421.3k421.4k421.5k421.6k421.7k421.8k421.9k422.0k422.1k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
vps20-Δ
  • vps20-delta
allele
Yes
vps20-∆loop∆MIM1allele
vps20-∆loopallele
NC_001145.3:g.421708A>Cvariant
SNP
  • missense variant
NC_001145.3:g.422003T>Avariant
SNP
  • synonymous variant
NC_001145.3:g.421266T>Gvariant
SNP
  • intergenic variant
NC_001145.3:g.421272A>Gvariant
SNP
  • intergenic variant
NC_001145.3:g.421314A>Gvariant
SNP
  • intergenic variant
NC_001145.3:g.421766G>Avariant
SNP
  • synonymous variant
NC_001145.3:g.421309A>Tvariant
SNP
  • intergenic variant
Showing 1 - 10 of 16 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
421.5k421.6k421.7k421.8k421.9k422.0k422.1kYMR077C_id001 (VPS20)YMR077C_id006 (VPS20)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

173 interactor genes based on 267 annotations
VPS20 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ADY3Saccharomyces cerevisiae
protein
  • two hybrid
PMID:22875988
protein
ASK1Saccharomyces cerevisiae
protein
  • two hybrid
PMID:10688190
protein
BDF1Saccharomyces cerevisiae
protein
  • two hybrid
PMID:22875988
protein
BRO1Saccharomyces cerevisiae
protein
  • protein complementation assay
PMID:34908216
protein
BRO1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:34908216
protein
BUL2Saccharomyces cerevisiae
protein
  • two hybrid
PMID:22875988
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CHM7Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:30942170
protein
CIK1Saccharomyces cerevisiae
protein
  • two hybrid
PMID:22875988
protein
COG3Saccharomyces cerevisiae
protein
  • two hybrid
PMID:22875988
Showing 1 - 10 of 134 rows
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Genetic Interactions

VPS20 role
VPS20 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ACT1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ACT1Saccharomyces cerevisiae
unspecified role
synthetic haploinsufficiency (sensu BioGRID)
  • haploinsufficient
PMID:17167106
unspecified role
ARC40Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ARD1Saccharomyces cerevisiae
unspecified role
synthetic growth defect (sensu BioGRID)
  • vegetative growth
PMID:16487579
unspecified role
ARP4Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ARP4Saccharomyces cerevisiae
unspecified role
synthetic lethality (sensu BioGRID)
  • inviable
PMID:18676811
unspecified role
AXL1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BCK1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BRE1Saccharomyces cerevisiae
unspecified role
synthetic growth defect (sensu BioGRID)
  • vegetative growth
PMID:16487579
unspecified role
BRL1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
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