Version: 8.0.0
Date: Tue Jan 28 2025
SIS1
Saccharomyces cerevisiaeSGD:S000004952
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

SIS1

Species
Saccharomyces cerevisiae
Symbol
SIS1
Name
SIt4 Suppressor
Synonyms
  • YNL007C
Biotype
protein coding gene
Automated Description
Enables misfolded protein binding activity. Involved in several processes, including detection of misfolded protein; gene expression; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of cytosolic small ribosomal subunit. Is active in cytosol and nucleolus. Used to study autosomal dominant limb-girdle muscular dystrophy type 1 and congenital myopathy 21. Human ortholog(s) of this gene implicated in congenital myopathy 21 and primary ciliary dyskinesia 34. Orthologous to several human genes including DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1).
SGD Description
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24078:SF519
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          SIS1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            SIS1 role
            SIS1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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