Version: 8.0.0Date: Tue Jan 28 2025
Gene
MSG5
- Species
- Saccharomyces cerevisiae
- Symbol
- MSG5
- Name
- Multicopy Suppressor of GPA1
- Synonyms
- YNL053W
- Biotype
- protein coding gene
- Automated Description
- Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of cell integrity MAPK cascade; pheromone response MAPK cascade; and regulation of fungal-type cell wall organization. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including DUSP1 (dual specificity phosphatase 1); DUSP10 (dual specificity phosphatase 10); and DUSP16 (dual specificity phosphatase 16).
- SGD Description
- Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10159:SF527
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXIV:529942...531411 + (1.47 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.