Version: 8.0.0
Date: Tue Jan 28 2025
THO2
Saccharomyces cerevisiaeSGD:S000005083
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

THO2

Species
Saccharomyces cerevisiae
Symbol
THO2
Name
suppressor of the Transcriptional defect of Hpr1 by Overexpression
Synonyms
  • LDB5
  • RLR1
Biotype
protein coding gene
Automated Description
Enables nucleic acid binding activity. Involved in several processes, including DNA metabolic process; cellular response to azide; and gene expression. Located in chromosome, telomeric region and nucleus. Part of THO complex part of transcription export complex and nucleoplasmic THO complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2).
SGD Description
Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21597:SF0
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          THO2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            THO2 role
            THO2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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