Version: 8.0.0Date: Tue Jan 28 2025
Gene
age-1
- Species
- Caenorhabditis elegans
- Symbol
- age-1
- Name
- AGEing alteration 1
- Synonyms
- B0334.8
- CELE_B0334.8
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Is expressed in anchor cell; hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); primary immunodeficiency disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
- WB Description
- age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrII:11519328...11527054 - (7.73 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.