Version: 8.0.0Date: Tue Jan 28 2025
Gene
aha-1
- Species
- Caenorhabditis elegans
- Symbol
- aha-1
- Name
- Aryl Hydrocarbon receptor Associated protein 1
- Synonyms
- C25A1.11
- CELE_C25A1.11
- Biotype
- protein coding gene
- Automated Description
- Enables DNA binding activity; DNA-binding transcription factor activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and social behavior. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anal region; epithelial system; gonadal primordium; nervous system; and vulva. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator) and ARNT2 (aryl hydrocarbon receptor nuclear translocator 2).
- WB Description
- aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; AHA-1 interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously; AHA-1 also physically interacts with CKY-1, and when co-expressed in vitro, an AHA-1/CKY-1 complex exhibits sequence-specific DNA binding; when co-expressed in cultured cells, the AHA-1/CKY-1 complex can stimulate reporter gene transcription;
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23042
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:10193925...10196997 - (3.07 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.