Version: 8.0.0
Date: Tue Jan 28 2025
ahr-1
Caenorhabditis elegansWB:WBGene00000096
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ahr-1

Species
Caenorhabditis elegans
Symbol
ahr-1
Name
Aryl Hydrocarbon Receptor related 1
Synonyms
  • C41G7.5
  • CELE_C41G7.5
Biotype
protein coding gene
Automated Description
Enables DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of locomotion and response to xenobiotic stimulus. Predicted to be part of nuclear aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including G2; TL.pa; TL.ppp; neurons; and phasmid socket cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to several human genes including AHR (aryl hydrocarbon receptor).
WB Description
ahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 activity is required for specification of RMEL and RMER GABAergic neuron cell fate and negative regulation of spontaneous movement; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10649
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ahr-1 molecule type
          Interactor gene
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            Genetic Interactions

            ahr-1 role
            ahr-1 genetic perturbation
            Interactor gene
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            Interactor role
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