Version: 8.0.0
Date: Tue Jan 28 2025
air-2
Caenorhabditis elegansWB:WBGene00000099
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

air-2

Species
Caenorhabditis elegans
Symbol
air-2
Name
Aurora/Ipl1 Related kinase 2
Synonyms
  • B0207.4
  • CELE_B0207.4
Biotype
protein coding gene
Automated Description
Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Is expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; spermatogenic failure 5; and uterine cancer. Orthologous to several human genes including AURKB (aurora kinase B).
WB Description
air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24350
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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        Transgenic Alleles

        Species
        (carrying the transgene)
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        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.9372M5.9374M5.9376M5.9378M5.9380M5.9382M5.9384M5.9386M5.9388M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            air-2 molecule type
            Interactor gene
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              Genetic Interactions

              air-2 role
              air-2 genetic perturbation
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