Gene

aqp-1

Species
Caenorhabditis elegans
Symbol
aqp-1
Name
AQuaPorin or aquaglyceroporin related 1
Synonyms
  • CELE_F32A5.5
  • dod-4
Biotype
protein coding gene
Automated Description
Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Is expressed in intestine and pharynx. Orthologous to several human genes including AQP10 (aquaporin 10); AQP3 (aquaporin 3 (Gill blood group)); and AQP7 (aquaporin 7).
WB Description
aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43829
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.2360M7.2362M7.2364M7.2366M7.2368M7.2370M7.2372M7.2374M7.2376M7.2378M7.2380M7.2382M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions