Version: 8.0.0
Date: Tue Jan 28 2025
aqp-2
Caenorhabditis elegansWB:WBGene00000170
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

aqp-2

Species
Caenorhabditis elegans
Symbol
aqp-2
Name
AQuaPorin or aquaglyceroporin related 2
Synonyms
  • C01G6.1
  • CELE_C01G6.1
Biotype
protein coding gene
Automated Description
Enables water channel activity. Involved in water transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in excretory cell; hypodermis; and muscle cell. Orthologous to several human genes including AQP10 (aquaporin 10); AQP3 (aquaporin 3 (Gill blood group)); and AQP7 (aquaporin 7).
WB Description
aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43829
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          aqp-2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            aqp-2 role
            aqp-2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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