ATF (cAMP-dependent transcription factor) family 2
Synonyms
CELE_K08F8.2
K08F8.2
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in digestive tract; egg-laying apparatus; excretory system; neurons; and ventral nerve cord. Orthologous to human NFILZ (NFIL3 like basic leucine zipper) and NFIL3 (nuclear factor, interleukin 3 regulated).
WB Description
atf-2 encodes a cAMP-dependent transcription factor paralogous to CES-2, a bZip-like transcription factor that plays a key role in regulation of apoptosis; atf-2 activity is required for excretory duct cell development and essential for embryonic development; in regulating excretory duct cell development, ATF-2 controls expression of lin-48; in vitro, ATF-2 binds the regulatory regions of LIN-48 and the autophagy genes BEC-1, and LGG-1; loss of atf-2 activity results in increased LGG-1 and BEC-1 expression, suggesting that ATF-2 negatively regulates lgg-1 and bec-1 expression in vivo; ATF-2 and CES-2 can physically interact in vivo; atf-2 is broadly expressed in embryos, and is also seen in larvae and adults.