Predicted to enable biotin--[biotin carboxyl-carrier protein] ligase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. Is expressed in Psub1. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase).
WB Description
bpl-1 encodes an ortholog of biotin ligase/holocarboxylase synthetase (called biotin ligase in bacteria, and holocarboxylase synthetase in mammalian or animal systems); it is orthologous to human HOLOCARBOXYLASE SYNTHETASE (HLCS; OMIM:253270), which when mutated leads to HLCS deficiency.