Version: 8.0.0Date: Tue Jan 28 2025
Gene
brc-1
- Species
- Caenorhabditis elegans
- Symbol
- brc-1
- Name
- BRCa homolog (tumor suppressor gene Brca1) 1
- Synonyms
- C36A4.8
- CELE_C36A4.8
- Biotype
- protein coding gene
- Automated Description
- Enables ubiquitin protein ligase activity. Involved in several processes, including DNA repair; cellular response to ionizing radiation; and nuclear chromosome segregation. Part of BRCA1-BARD1 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated).
- WB Description
- brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onsetbreast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer withBRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, theDNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormallyhigh levels of CEP-1-dependent germ cell apoptosis (both with and withoutgamma-irradiation) and hypersensitivity to gamma-irradiation (e.g.,abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another,probably through their N-terminal RING domains, in yeast two-hybridexperiments and pull-down assays; BRC-1/BRD-1 heterodimers may interactwith RAD-51 and other proteins via mutual binding to UBC-9; brc-1 isgenetically dispensable for the induction of nuclear ATL-1 foci bygamma-irradiation or hydroxyurea.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13763
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIII:3853102...3862968 - (9.87 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.